MYO9B, myosin IXB, 4650

N. diseases: 65; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005823
Disease: Blood Pressure
Blood Pressure 		0.100 GeneticVariation phenotype GWASDB Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. 21909110 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 GeneticVariation disease GWASDB A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. 20852631 2010
CUI: C0489786
Disease: Height
Height 		0.100 GeneticVariation phenotype GWASDB Hundreds of variants clustered in genomic loci and biological pathways affect human height. 20881960 2010
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 Biomarker disease GENOMICS_ENGLAND Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions. 21143118 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET Based on this review, we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia in 223 families, 108 unrelated individuals with schizophrenia and 120 controls. 21688385 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET We demonstrate significant association of allelic variants in MYO9B with schizophrenia. 17948900 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET The present study was then undertaken to examine whether the association of MYO9B with schizophrenia could be replicated in a Chinese population. 25710847 2015
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. 16282976 2005
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN No MYO9B variants or MYO9B haplotypes were found associated with CD, either before or after stratification of the patients for the human leucocyte antigen (HLA)-DQ2-positive risk factor. 17176439 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN This suggests that genetic variation in MYO9B is associated with CD, SLE, and RA and that MYO9B is a general risk factor for autoimmunity. 17584584 2007
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 Biomarker disease LHGDN In all, 337 unrelated patients with CD, 424 parents (212 sets), and 452 healthy individuals were genotyped for the IGR2198a_1, rs12521868, rs1050152, and rs2631367 SNPs (IBD5 locus) and the rs962917, rs2305764, and rs1545620 SNPs of the MYO9B gene by the restriction enzyme method and the TaqMan system ABI PRISM 7700, respectively. 17667713 2007
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN Lack of reproducibility could be explained by no or negligible contribution of MYO9B to the genetic predisposition to CD in the Swedish/Norwegian population. 16720215 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN In conclusion, MYO9B is not involved in CD susceptibility in the Italian population. 16943798 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 GeneticVariation disease LHGDN We demonstrate significant association of allelic variants in MYO9B with schizophrenia. 17948900 2008
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 GeneticVariation group LHGDN Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease LHGDN Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.070 GeneticVariation disease LHGDN Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.050 Biomarker group LHGDN There has long been discussion on the correlation between schizophrenia and autoimmune diseases (especially celiac disease), which makes the recently discovered celiac disease risk factor, MYO9B, an attractive functional and positional candidate gene for schizophrenia. 17948900 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 GeneticVariation disease LHGDN MYO9B gene polymorphisms are associated with autoimmune diseases in Spanish population. 17584584 2007
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.010 GeneticVariation disease LHGDN This suggests that genetic variation in MYO9B is associated with CD, SLE, and RA and that MYO9B is a general risk factor for autoimmunity. 17584584 2007
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Evaluation and application of summary statistic imputation to discover new height-associated loci. 29782485 2018
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Hundreds of variants clustered in genomic loci and biological pathways affect human height. 20881960 2010
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.100 GeneticVariation group GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019